Protein name:
Free fatty acid receptor 1 ;
Alternative:
G-protein coupled receptor 40 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Function:
Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Protein Attributes:
50:
MDLPPQLSFA | LYVSAFALGF | PLNLLAIRGA | VSHAKLRLTP | SLVYTLHLAC |
100:
SDLLLAITLP | LKAVEALASG | VWPLPLPFCP | VFALAHFAPL | YAGGGFLAAL |
150:
SAGRYLGAAF | PFGYQAIRRP | CYSWGVCVAI | WALVLCHLGL | ALGLEAPRGW |
200:
VDNTTSSLGI | NIPVNGSPVC | LEAWDPDSAR | PARLSFSILL | FFLPLVITAF |
250:
CYVGCLRALV | HSGLSHKRKL | RAAWVAGGAL | LTLLLCLGPY | NASNVASFIN |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Rat Free fatty acid receptor 1
ELISA Kit for Rat Free fatty acid receptor 1
ELISA Kit for Rat Free fatty acid receptor 1
CLIA Kit for Rat Free fatty acid receptor 1
CLIA Kit for Rat Free fatty acid receptor 1
CLIA Kit for Rat Free fatty acid receptor 1
Polyclonal Antibody for Rat Free fatty acid receptor 1
Polyclonal Antibody for Rat Free fatty acid receptor 1
Polyclonal Antibody for Rat Free fatty acid receptor 1
Monoclonal Antibody for Rat Free fatty acid receptor 1
Monoclonal Antibody for Rat Free fatty acid receptor 1
Monoclonal Antibody for Rat Free fatty acid receptor 1
Protein for Rat Free fatty acid receptor 1
Protein for Rat Free fatty acid receptor 1
Protein for Rat Free fatty acid receptor 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"The orphan G protein-coupled receptor GPR40 is activated by medium and long-chain fatty acids."
Briscoe C.P.
,
Tadayyon M.
,
Andrews J.L.
,
Benson W.G.
,
Chambers J.K.
,
Eilert M.M.
,
Ellis C.
,
Elshourbagy N.A.
,
Goetz A.S.
,
Minnick D.T.
,
Murdock P.R.
,
Sauls H.R. Jr.
,
Shabon U.
,
Spinage L.D.
,
Strum J.C.
,
Szekeres P.G.
,
Tan K.B.
,
Way J.M.
,
Ignar D.M.
,
Wilson S.
,
Muir A.I.
more...
J. Biol. Chem.278:11303-11311(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
strain :
Sprague-Dawley .
2.
"Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40."
Itoh Y.
,
Kawamata Y.
,
Harada M.
,
Kobayashi M.
,
Fujii R.
,
Fukusumi S.
,
Ogi K.
,
Hosoya M.
,
Tanaka Y.
,
Uejima H.
,
Tanaka H.
,
Maruyama M.
,
Satoh R.
,
Okubo S.
,
Kizawa H.
,
Komatsu H.
,
Matsumura F.
,
Noguchi Y.
,
Shinohara T.
,
Hinuma S.
,
Fujisawa Y.
,
Fujino M.
more...
Nature422:173-176(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY